Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

Oliver's and Rodriguez-Pereyra's important interpretation of the problem of universals as one concerning truthmakers neglects something crucial: that there is a numerical identity between numerically distinct particulars. The problem of universals is rather how to resolve the apparent contradiction that the same things are both numerically distinct and numerically identical. Baxter's account of instantiation as partial identity resolves the apparent contradiction. A seeming objection to this account is that it appears to make instantiation symmetric, since partial identity is symmetric. (...) Armstrong's standard reply is that the difference between a particular and a universal is what makes instantiation asymmetric. Brown suggests, though, that the instantiation of a universal by a universal is sometimes symmetric. However, the examples on which he relies are not universals. (shrink)

Thomas L. Friedman's recent book on globalization, The Lexus and the Olive Tree, sees a religious value in globalization: “globalization emerges from below … from people's very souls and from their deepest aspirations” (1999, 338). Pierre Teilhard de Chardin made similar claims in 1920, calling globalization the “deep‐rooted religious movement of our age” (Teilhard 1979, 211). He came to this awareness through his experience in World War I. There he began connecting globalization to its roots in evolution and to the (...) mystics’ desire for the “All,” a desire he saw animating the work of believing and unbelieving scientists. He found confirmation of his ideas in the letters of Saint Paul, who told of God eventually filling all things. Teilhard used the vocabulary of mysticism to describe global developments in technology, industry, politics, and the environment, and the ardor of his texts has led to their being widely used for secular gatherings on global subjects. (shrink)

En France, un différend très intéressant touchant l’opinion de Kant sur la guerre vient d’être résolu. En voici le compte-rendu d’après les sources dont nous disposons. Le célèbre journal politique « Le temps » publiait dans le numéro du 17 mars 1899 un rapport sur « Une conférence de M. Brunetière » : celui-ci avait donné le 16 mars une conférence à l’hippodrome de Lille, devant environ 3 000 personnes....

Recent, well-publicized scandals, involving unethical conduct have rekindled interest in academic misconduct. Prior studies of academic misconduct have focussed exclusively on situational factors (e.g., integrity culture, honor codes), demographic variables or personality constructs. We contend that it is important to also examine how␣these classes of variables interact to influence perceptions of and intentions relating to academic misconduct. In a sample of 217 business students, we examined how integrity culture interacts with Prudence and Adjustment to explain variance in estimated frequency of (...) cheating, suspicions of cheating, considering cheating and reporting cheating. Age, integrity culture, and personality variables were significantly related to different criteria. Overall, personality variables explained the most unique variance in academic misconduct, and Adjustment interacted with integrity culture, such that integrity culture had more influence on intentions to cheat for less well-adjusted individuals. Implications for practice are discussed and future research directions are offered. (shrink)

The purpose of this article is to examine stakeholder identification and prioritization by managers using the power, legitimacy, and urgency framework of Mitchell et al. (Academy of Management Review 22, 853–886; 1997). We use a multi-method, comparative case study of two large-scale sporting event organizing committees, with a particular focus on interviews with managers at three hierarchical levels. We support the positive relationship between number of stakeholder attributes and perceived stakeholder salience. Managers’ hierarchical level and role have direct and moderating (...) effects on stakeholder identification and perceived salience. We also found that most stakeholders were definitive, dominant, or dormant types – the other five types were rare. Power has the most important effect on salience, followed by urgency and legitimacy. Based on our case study, we offer several ways to advance the theory of stakeholder identification and salience. (shrink)

Despite its central role in his important theories of self and external world, Hume’s account of numerical identity has been neglected or misunderstood. The account is designed as a response to a difficulty concerning identity apparently original with Hume. I argue that the problem is real, crucial, and remains unresolved today. Hume’s response to the difficulty enlists his idiosyncratic, empiricist views on time: time consists of discrete, partless moments, some of which coexist with successions of others. Time is more like (...) a wall of variously sized bricks than like a continuous line. Hume’s arguments that time (and space) are not infinitely divisible have met with literal contempt. I show that his unusual views are motivated and consistent. The topic of identity leads naturally to Hume’s account of personal identity and his later retraction--one of the most widely discussed topics in Hume scholarship. I give a new, straightforward explanation of the retraction, by arguing that Hume’s views on consciousness preclude his prior account of the self as a fiction. I then suggest that Hume’s fundamental problem for personal identity is his general difficulty concerning identity. Discussing Hume’s metaphysics raises perhaps the most central and difficult topic in Hume scholarship--how to reconcile the constructive, theoretical Hume with the skeptical Hume. The prevailing view for the last century has been that Hume’s skepticism is limited, leaving room for his theorizing. I argue, rather, that Hume is an unlimited Pyrrhonian skeptic in relevant respects, and that this interpretation of him best reconciles his two sides. (shrink)

Three major strategies exist for the protection of endangered habitat and species: (1) land acquisition programs, (2) government legislation and regulatory agencies, and (3) "stewardship" programs that are voluntary and community-based. While all of these strategies have merit, we suggest that stewardship holds particular advantages and should be considered more often as a strategy of first choice. In this article, we examine the Municipal Wetland Stewardship program of Newfoundland, a popular and successful Canadian policy for the local protection of wetlands. (...) Important issues are at stake: competing philosophical foundations for managerial ecology, the value of "local ecological knowledge," principles of community-based conservation, the question of whether stewardship empowers local communities or controls them from afar, and ethical conflicts around American colonialism, hunting, and ecotourism. The results suggest that despite some potentially problematic ironies, the Newfoundland program provides a model for a public policy aimed both at the pragmatics of biophysical sustainability and at the ideals of environmental ethics, social justice, and democratic politics. (shrink)

The task of making a new Teubner edition of the Anacreontea has led me to realize how much still remains to be done for the text of these once celebrated but no w little-read poems, for which we depend on the same tenth-century manuscript as for the Palatine Anthology. In what follows I attempt to justify the new emendations adopted in the edition, and one or two old ones which have generally been dismissed.

The work with which I am concerned is not the one that appears under the name of Tryphon in Rhetores Graeci, viii. 726–60 Walz, iii. 191–206 Spengel, but the one that appears under the name of Gregory of Corinth, viii. 761–78 W. and iii. 215–26 Sp. What I now offer amounts to a makeshift edition. I call it makeshift, because I have not sought out and assessed all existing manuscripts of the work, or versed myself in Greek grammatical writing to (...) the extent that a serious editor would have to do; I offer it because, whatever its deficiencies, it represents a more complete and a recensionally better founded text than those of the three existing editions, the most recent of which is now 109 years old. (shrink)

Clahsen's view on language is intimately linked with the Chomskian distinction between competence and performance. He uses performance to verify theoretical assumptions about the underlying structure of competence. Using mostly off-line tasks, he may fail to answer the question of how language is generated and perceived in natural situations.

Pre- and postmeasures of course knowledge correlated more strongly and consistently with course performance variables (essay quizzes, course project, multiple-choice exams, and total course credit)than did pre- and postmeasures of generic critical thinking. In addition, the total sample (N =126) improved significantly on course knowledge from the pre- to the postassessment but changed minimally on critical thinking. The extent and pattern of change in critical thinking differed somewhat for students making high and low grades in the course. High-grade students achieved (...) significantly more favorable changes on both critical thinking and course knowledge than did the low-grade students. (shrink)

(2005). Reflections on the Appointment of Dr. Edmund Pellegrino to the President's Council on Bioethics. The American Journal of Bioethics: Vol. 5, No. 6, pp. W8-W9. doi: 10.1080/15265160500388640.

This comes near to satisfying; but even with ipsa the change of subject from tecta to plaustra is awkward, and exsultant is inappropriate to a lumbering plaustrum . I suggest reading cisia instead of ipsa. The cisium was a fast light two-wheeled vehicle which might well jump up on a rough road; and the first three letters cis could have become the -es of the MS exsultantes. Two further points: lapis uiai is not ‘a stone on the road’ , but (...) rather the stone of the road, i.e. the paving; and utrimque is not ‘on one side or the other’ but ‘on both sides’. There remains Ernout's objection that the suppression of the final s of lapis is unlikely. One can only say that no one would have ventured to introduce by conjecture pendentibu' structas or manantibu' stillent, but both are found in Lucretius' text. (shrink)

A veritable cookbook for individuals or corporations seeking funding from the federal government, The Complete Writing Guide to NIH Behavioral Science Grants contains the latest in technical information on NIH grants, including the new electronic submission process. Some of the most successful grant writers in history have contributed to this volume, offering key strategies as well as tips and suggestions in areas that are normally hard to find in grant writing guides, such as budgeting, human subjects, and power analysis. A (...) "who's who" among grant reviewers, this guidebook provides "inside" information as to why some grants are scored well while others flounder during review. A must-read for both entry level grant writers making headway in the complex NIH grant system for the first time as well as more seasoned investigators who can't seem to break the barrier to funded research grants, Drs. Scheier and Dewey's comprehensive volume provides simple and clear explanations into the reasons why some grants get funded, and a step-by-step guide to writing those grants. (shrink)